There is a new clinical trial for insulin nasal spray in the treatment of Mild Cognitive Impairment and Alzheimer’s disease. I was very excited back in 2011 when they presented the first trial results. (Click here for my earlier blog including a video summarizing the 2011 trial).
I want Dan to get an AMYVID pet scan and find out once and for all if he has Alzheimer’s pathology.
“Dan, please get the scan. If it’s positive I would want you in this trial yesterday. If it’s negative you can stop worrying about Alzheimer’s,” I plead.
“I don’t worry about it except when you are constantly bringing it up!" he grinds out.
“Dan, I speak to you about this topic ONCE a year. ONCE.” Dan feels that I am constantly bringing this up because he is constantly demonstrating his impairments and when it is obvious even to him (see last blog entry), in his mind, it is me pointing out his impairments.
There is zero downside to him getting the PET scan. If it's positive - we get him in this trial. If it is negative - we can stop worrying that he will progress to AD.
The researchers hope the drug will be available in 3-4 years from the start of the new trial, so it will be 2017-18 before this drug would be on the market.
Even if Dan was on the placebo the first 12 months of the trial, he'd get the insulin the last 6 months (that's the way it's set up). Then all trial participants get to stay on it - they do not have to wait through the FDA approval process. So that means Dan could arrest his disease within months vs. another 3-4 years of irreversible brain damage (if he has AD).
“I’ve told you: if I have it, I don’t want to know!” Dan insists.
This is the worst imaginable irony. Dan’s impairments are going to keep him from getting help with his impairments. His reasoning button is broken.
I have recruited our sons to lobby him. I am praying. This is so frustrating!